May 3, 2010
Posted in Pregnancy Care
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Crohn’s Disease Treatment Options during Pregnancy



Crohn’s disease is an acute, long-standing ailment leading to intestinal and bowel inflammation as well as ulceration (sores). Though the disease develops at any age, it is prevalently found to affect people in age bracket of fifteen to thirty years.

Individuals affected with the disease experience alternating phases of being symptomatic and being in remission. Symptoms comprise of acute loose bowels, bleeding from rectum, weight reduction, fever, stomach pains and soreness, sense of fullness or accruement in the abdominal area and postponed or stunted development in kids.

Crohn’s Disease and its impact on Pregnancy

In several cases, pregnancy has a favorable effect on Crohn’s disease. Gestational term could assuage the symptoms since it has a suppressing action on a woman’s immune system. This occurs for preventing the body from rejecting the fetus.

Conceiving could safeguard a woman from disease flare-ups later on in life and could additionally lower necessity for surgical intervention in the future. This is due to pregnancy leading to production of relaxin hormone. Relaxin halts untimely uterine contractions and it is believed that it could additionally hinder scars tissue from forming.

Females having Crohn’s disease experience normal gestational terms and child birth at the analogous rates as females that do not have the disease. The problem arises chiefly when the disease is in an active state which could raise risk of suffering from miscarriage, preterm birth and still births. However, females having inactive form of the disease are additionally at greater risk of miscarriages in comparison to expectant mothers on an average.

Moreover, women having active Crohn’s disease have problems trying to conceive as compared to when the disease is asymptomatic. Preferably, a woman must be in sound heath and in remission while she is attempting conception.

Crohn’s Disease Treatment Choices for Pregnant Women

Generally, Crohn’s disease treatment medications are the same even for pregnant women, although it could, in case a woman’s condition changes. In the case of particular forms of medications for treating Crohn’s disease, solely thalidomide and antibiotic course should be evaded as they could be harmful to the foetus.

However medications from the aminosalicylate group also known as 5-ASA medications (mesalamine, balsalazide, olsalazine, sulfasalazine) are safe Crohn’s disease treatment options during pregnancy and do not raise chances of complications and are safe to use during breastfeeding.

Biological medications like adalimumab-Humira, infliximab-Remicade are safe for usage among pregnant women and are not excreted in breast milk.

Medications affecting the immune system known as immunomodulator and immunosuppressive are safe for use during pregnancy when taken in normal doses. The exclusion to this case is methotrexate which is best avoided during pregnancy or by both partners attempting conception. Methotrexate causes a host of complications like fetal death, birth flaws and must not be used during breastfeeding.

Women taking Sulphasalazine must especially get adequate amounts of folic acid since the drug hampers folic acid from being absorbed by the body. Folic acid is vital during pregnancy since it averts neural tube anomalies like spina bifida.

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